CK16 Mouse mAb(6F6)

产品编号 ： SY079 优

抗体来源： Mouse

应用:  IHC

反应性:   H,M,R

MW：51kD(Observed）

蛋白名称

CK16

来源

Mouse monoclonal antibody is prepared by immunizing synthetic peptide coupled to KLH.

特异性

The CK16 mouse monoclonal antibody can detect endogenous CK16 proteins.

存储

Store at -20°C. Stable for one year from the date of shipment.

组成

1mg/ml in PBS, pH 7.4, containing 0.02% sodium azide and 50% glycerol.

稀释比例

 IHC 1:200

(Optimal dilutions should be determined by the end user)

浓度

1 mg/ml

实测条带

54kD

克隆性

Monoclonal

同种型

IgG1

别名

Cytokeratin16 antibody, Keratin type I cytoskeletal 16 antibody, KRT 16 antibody, Keratin16 antibody

Keratin 16 is expressed in keratinocytes, which are undergoing rapid turnover in the suprabasal region (also known as hyperproliferation-related keratins). Keratin 16 is absent in normal breast tissue and in noninvasive breast carcinomas. Only 10% of the invasive breast carcinomas show diffuse or focal positivity. Reportedly, a relatively high concordance was found between the carcinomas immunostaining with the basal cell and the hyperproliferation-related keratins, but not between these markers and the proliferation marker Ki-67. This supports the conclusion that basal cells in breast cancer may show extensive proliferation, and that absence of Ki-67 staining does not mean that (tumor) cells are not proliferating.