概述
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产品编号 ： SY160 |
抗体来源： Mouse |
应用: WB, IHC |
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反应性: H |
MW：116(Pro),89(Active)kD(Observed） |
|
Western Blot
Western blot analysis of 1) Jurkat ,2) Hela, with SY160 diluted at 1:2,000.
IHC
Immunohistochemical analysis of paraffin-embedded human Tonsil Tissue using Cleaved PARP （SY160）Mouse mAb diluted at 1:500.
产品描述
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蛋白名称 |
Cleaved PARP |
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来源 |
Mouse monoclonal antibody is prepared by immunizing synthetic peptide coupled to KLH. |
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特异性 |
The Cleaved PARP antibody can recognize endogenous pro and active PARP protein. |
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存储 |
Store at -20°C. Stable for one year from the date of shipment |
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组成 |
in PBS, pH 7.4, containing 0.02% sodium azide and 50% glycerol. |
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稀释比例 |
WB 1:1,000-3,000 IHC 1:200-500 (Optimal dilutions should be determined by the end user) |
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浓度 |
1 mg/ml |
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实测条带 |
116(Pro),89(Active)kD(Observed） |
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克隆性 |
Monoclonal |
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同种型 |
IgG1 |
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别名 |
PARP-1, Poly(ADP ribose) polymerase 1, sPARP1,ADPRT1, ADP ribosyltransferase NAD(+) |
背景
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Poly [ADP-ribose] polymerase 1 (PARP-1) also known as NAD+ ADP-ribosyltransferase 1 or poly[ADP-ribose] synthase 1 is an enzyme that in humans is encoded by the PARP1 gene. PARP1 has a role in repair of single-stranded DNA (ssDNA) breaks. Knocking down intracellular PARP1 levels with siRNA or inhibiting PARP1 activity with small molecules reduces repair of ssDNA breaks. In the absence of PARP1, when these breaks are encountered during DNA replication, the replication fork stalls, and double-strand DNA (dsDNA) breaks accumulate. |
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