COX1/Cyclooxygenase 1 Rabbit pAb

产品编号 ： SY091  

抗体来源：Rabbit

应用:  WB, IHC

反应性:      H

MW：70kD(Observed）

蛋白名称

 COX1/Cyclooxygenase 1

来源

Rabbit polyclonal antibody is prepared by immunizing synthetic peptide coupled to KLH.

特异性

The COX1 rabbit polyclonal antibody can detect endogenous COX1 proteins.

存储

Store at -20°C. Stable for one year from the date of shipment.

组成

1mg/ml in PBS, pH 7.4, containing 0.02% sodium azide and 50% glycerol.

稀释比例

 WB 1:1,000

(Optimal dilutions should be determined by the end user)

浓度

1 mg/ml

实测条带

70kD

克隆性

Polyclonal

同种型

IgG

别名

PGH synthase 1 antibody, PGHS1 antibody, Prostaglandin G/H synthase 1 antibody, PTGHS antibody

Cyclooxygenase-1 (COX-1), also known as prostaglandin G/H synthase 1, prostaglandin-endoperoxide synthase 1 or prostaglandin H2 synthase 1, is an enzyme that in humans is encoded by the PTGS1 gene. There are two isozymes of COX encoded by distinct gene products: a constitutive COX-1 (this enzyme) and an inducible COX-2, which differ in their regulation of expression and tissue distribution. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors. A splice variant of COX-1 termed COX-3 was identified in the CNS of dogs, but does not result in a functional protein in humans. Two smaller COX-1-derived proteins (the partial COX-1 proteins PCOX-1A and PCOX-1B) have also been discovered, but their precise roles are yet to be describedGalectin 3 is one of the more extensively studied members of this family and is a 30 kDa protein. Due to a C-terminal carbohydrate binding site, Galectin 3 is capable of binding IgE and mammalian cell surfaces only when homodimerized or homooligomerized. Galectin 3 is normally distributed in epithelia of many organs, in various inflammatory cells, including macrophages, as well as dendritic cells and Kupffer cells. The expression of this lectin is up-regulated during inflammation, cell proliferation, cell differentiation and through trans-activation by viral proteins.